This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]

Ret Proto-Oncogene;
Cadherin-Related Family Member 16;
Rearranged During Transfection;
RET Receptor Tyrosine Kinase;
Cadherin Family Member 12;
Proto-Oncogene C-Ret;
EC 2.7.10.1;
CDHF12;
CDHR16;
RET51;
PTC;
Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1, Hirschsprung Disease) ;
Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1;
Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret;
Hydroxyaryl-Protein Kinase;
RET Transforming Sequence;
Receptor Tyrosine Kinase;
Hirschsprung Disease 1;
Oncogene RET;
EC 2.7.10;
RET-ELE1;
MEN2B;
HSCR1;
MEN2A;
MTC1; RET_HUMAN.

Mouse,Rat,Human,Dog,Rabbit

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

122kD

5979

P07949

https://www.uniprot.org/uniprotkb/P07949

Cell membrane; Single-pass type I membrane protein; Endosome membrane;

KLH conjugated synthetic peptide derived from human RET

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.