This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].

CD124;
IL 4R alpha;
IL-4 receptor subunit alpha;
IL-4-binding protein;
IL-4R subunit alpha;
IL-4R-alpha;
IL-4RA;
IL4-BP;
Il4r;
IL4R nirs variant 1;
IL4RA;
IL4RA_HUMAN;
Interleukin 4 receptor alpha chain;
Interleukin 4 receptor;
sIL4Ralpha/prot;
Soluble IL-4 receptor subunit alpha;
Soluble IL-4R-alpha;
Soluble interleukin-4 receptor subunit alpha

Human,protein

WB

WB 1:500-2000

88kD

16190

P16382

https://www.uniprot.org/uniprotkb/P16382

Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Isoform 1 and isoform 2 are highly expressed in activated T-cells.

KLH conjugated synthetic peptide derived from human IL-4R

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.