The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in the targeted degradation of IkB (1). IkB kinase alpha (IKK alpha), previously designated CHUK (2), interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, serines 32 and 36 (3). IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4). Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5). The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma (also designated NEMO), and each appears to make essential contributions to IkB phosphorylation (6). IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, interacting with NIK, IKK alpha and IKK beta and assembling them into an active kinase complex (7,8)

DKFZp781H1425;
DYS;
Dysautonomia (Riley Day syndrome hereditary sensory autonomic neuropathy type III);
Elongator complex protein 1;
ELP 1;
ELP1;
ELP1_HUMAN;
FD;
FLJ12497;
IKAP;
IkappaB kinase complex associated protein;
IkappaB kinase complex-associated protein;
ikbkap;
IKI 3;
IKI3;
IKK complex associated protein;
IKK complex-associated protein;
Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein;
OTTHUMP00000063889;
p150;
TOT 1;
TOT1

Mouse,Rat,Human,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

150kD

8518

Q9FNA4

https://www.uniprot.org/uniprotkb/Q9FNA4

Cytoplasm. Nucleus.

Expressed in meristematic tissues of in roots, stems, leaves, seedlings, cotyledons, guard cells, floral buds, flowers, siliques, and shoot apices.

KLH conjugated synthetic peptide derived from human IKAP

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.