High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI (Scavenger Receptor BI) protein binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Scavenging Receptor SR-BI plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.

85 kDa lysosomal membrane sialoglycoprotein;
CD36 and LIMPII Analogous 1;
CD36L1;
CD36L2;
CLA1;
HLGP85;
LGP85;
LIMP II;
Lysosome membrane protein II;
MGC138242;
SCARB1;
SCARB2;
Scavenger receptor class B member 2;
Scavenger Receptor Class B Type I;
SRBI;
SRBII.

Human,Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep

WB

WB 1:500-2000

61kD

949

Q8WTV0

https://www.uniprot.org/uniprotkb/Q8WTV0

Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.

Widely expressed.

The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.

KLH conjugated synthetic peptide derived from human Scavenger Receptor BI + BII

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.