Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin 5 is an isoform composed of three distinct subunits, alpha 3, beta 3 and gamma 2, which are bound to each other in a cross-shaped molecule by disulphide bonds. It is a complex glycoprotein thought to be involved in cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes. It is also involved in signal transduction via tyrosine phosphorylation of pp125-FAK and p80, and differentiation of keratinocytes. The laminin alpha 3 subunit is also thought to be a component of laminin 6 and laminin 7

E170;
Epiligrin 170 kDa subunit;
Epiligrin subunit alpha;
Kalinin subunit alpha;
LAMA3;
LAMA3A;
Laminin 5 alpha3;
Laminin A3;
laminin alpha 3;
laminin alpha3;
Laminin subunit alpha-3;
Laminin-5 subunit alpha;
Laminin-6 subunit alpha;
Laminin-7 subunit alpha;
laminin5 alpha 3;
Laminin5 alpha3;
LAMNA;
LOCS;
Nicein subunit alpha;
LAMA3_HUMAN.

Mouse,Human,Rat,Dog,Pig,Cow,Horse,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

367kD

3909

Q16787

https://www.uniprot.org/uniprotkb/Q16787

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Skin; respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expression of the subunit alpha-3 is observed in the CNS.

KLH conjugated synthetic peptide derived from human LAMA3

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.