Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

NR2C2_HUMAN;
Nuclear hormone receptor TR4;
Nuclear receptor subfamily 2 group C member 2;
Orphan nuclear receptor TAK1;
Orphan nuclear receptor TR4;
TAK1;
Testicular nuclear receptor 4;
Testicular receptor 4;
TR2R1;
TR4;
TR4 nuclear hormone receptor.

Mouse,Human,Rat,Chicken,Dog,Cow,Horse,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

65kD

826

P49116

https://www.uniprot.org/uniprotkb/P49116

Cytoplasm. Cell membrane. Translocates to the plasma membrane upon calcium binding.

KLH conjugated synthetic peptide derived from human NR2C2

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.