SPACA3 is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein.

1700025M08Rik;
ALLP17;
Cancer/testis antigen 54;
sperm acrosome associated 3;
CT54;
LYC3;
Lysozyme like sperm specific secretory protein ALLP17;
Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17;
Lysozyme-like protein 3;
LYZL3;
processed form;
SACA3_HUMAN;
SLLP1;
SPACA3;
Sperm acrosome associated 3;
Sperm acrosome membrane-associated protein 3;
Sperm lysozyme-like protein 1;
Sperm protein reactive with antisperm antibodies;
Sperm protein reactive with ASA; 1.

Human

IHC,IF,ICC,ELISA

IHC 1:50-1:200
IF 1:100-500
ICC 1:100-1:400
ELISA 1:5000-10000

23kD

124912

Q8IXA5

https://www.uniprot.org/uniprotkb/Q8IXA5

Secreted and Cytoplasmic vesicle > secretory vesicle > acrosome membrane. Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction.

The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta.

KLH conjugated synthetic peptide derived from human SPACA3

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.