This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008].

5HT transporter; 5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1; SERT; SERT1; SC6A4_HUMAN; SERT; SLC6A4; Sodium dependent serotonin transporter; Sodium-dependent serotonin transporter; Solute carrier family 6 member 4; sodium-dependent serotonin transporter; 5-hydroxytryptamine transporter; 5HT transporter; Na+/Cl- dependent serotonin transporter.

Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Sheep,GuineaPig

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

70kD

6532

P31645

https://www.uniprot.org/uniprotkb/P31645

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.

Expressed in platelets (at protein level).

KLH conjugated synthetic peptide derived from human 5-HTT

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.