SPCS3 (signal peptidase complex subunit 3), also known as SPC3, is a 180 amino acid single-pass type II membrane protein that localizes to both the microsome and the endoplasmic reticulum (ER) and belongs to the SPCS (signal peptidase complex subunit) family. Existing as a component of the microsomal signal peptidase complex which consists of five members, SPCS3 functions to remove signal peptides from proteins that are translated to the lumen of the ER. The gene encoding SPCS3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

DKFZp564J1864;
FLJ22649;
Microsomal signal peptidase 22/23 kDa subunit;
Microsomal signal peptidase 23 kDa subunit;
PRO3567;
Signal peptidase complex subunit 3;
Signal peptidase complex subunit 3 homolog (S. cerevisiae);
Signal peptidase complex subunit 3 homolog;
SPase 22 kDa subunit;
SPase 22/23 kDa subunit;
SPC22;
SPC22/23;
SPC3;
UNQ1841;
YLR066W.

Rat,Human,Mouse,Cow,Horse

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

20kD

60559

P61009

https://www.uniprot.org/uniprotkb/P61009

Endoplasmic reticulum and Microsome membrane;: Single-pass type II membrane protein

KLH conjugated synthetic peptide derived from human SPCS3

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.