O-sialoglycoprotein endopeptidases cleave the polypeptide backbone of membrane glycoproteins that contain clusters of O-linked sialoglycans. Osgep (O-sialoglycoprotein endopeptidase), also known as GCPL1, is a 335 amino acid protein that is a member of the peptidase M22 family. Osgep specifically cleaves the 31-Arg-l-Asp-32 bond in glycophorin A, but it does not cleave desialylated glycoproteins, unglycosylated proteins or glycoproteins that are only N-glycosylated. Though ubiquitously expressed at low levels, highest levels of Osgep are found in liver, skeletal muscle and kidney. OSGEPL1, also known as Qri7, is a 414 amino acid protein that belongs to the KAE1/YgjD family and exists as three alternatively spliced isoforms. In tRNAs that have codons beginning with adenine, OSGEPL1 is required for the formation of a threonylcarbamoyl group on adenosine.

FLJ20411;
GCPL-1;
GCPL1;
hOSGEP;
KAE1;
O sialoglycoprotein endopeptidase;
OSGEP;
OSGEP_HUMAN;
OSGEP1;
Pasteurella haemolytica metalloprotease homolog with glycoprotein substrates/gpc-like protein 1;
Probable O sialoglycoprotein endopeptidase;
Probable tRNA threonylcarbamoyladenosine biosynthesis protein osgep;
PRSMG1;
Prsmg1/Gcpl1;
t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep.

Mouse,Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

36kD

55644

Q9NPF4

https://www.uniprot.org/uniprotkb/Q9NPF4

Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas.

KLH conjugated synthetic peptide derived from human OSGEP

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.