Slitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all.

SLITRK 1; KIAA0918; KIAA1910; Leucine rich repeat containing protein 12; SLITRK 1; LRRC1; SLIT and NTRK like family, member 1.

Rat,Human,Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

76kD

114798

Q96PX8

https://www.uniprot.org/uniprotkb/Q96PX8

Membrane; Single-pass type I membrane protein (Potential).

Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.

KLH conjugated synthetic peptide derived from human Slitrk1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.