13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq].
Acetate kinase 1; Acetokinase 1; Activated CDC42 kinase 1; Activated Cdc42 associated kinase 1; Activated p21cdc42Hs kinase; Tyrosine kinase non receptor 2; Tyrosine kinase non-receptor protein 2; non-receptor protein tyrosine kinase ACK; ACK; TNK 2; Tnk2; ACK1; FLJ44758; FLJ45547; ACK 1; ACK-1; ACK1_HUMAN; Activated p21cdc42Hs kinase; FLJ44758; FLJ45547; Tyrosine kinase non receptor protein 2; p21cdc42Hs.
Human,Mouse,Rat,Chicken,Dog,Pig,Cow
WB,IHC,IF,ICC
WB 1:500-2000IHC 1:100-500IF 1:100-1:400ICC 1:100-1:400
119kD
10188
Q07912
Cell membrane. Nucleus. Endosome. Cell junction, adherens junction. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Membrane, clathrin-coated pit. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus. Co-localizes with EGFR on endosomes. Nuclear translocation is CDC42-dependent.
The Tyr-284 phosphorylated form shows asignificant increase in expression in breast cancers during theprogressive stages i.e. normal to hyperplasia (ADH), ductalcarcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymphnode metastatic (LNMM) stages. It also shows a significant increasein expression in prostate cancers during the progressive stages.
KLH conjugated synthetic peptide derived from human Ack1
Rabbit
Polyclonal
IgG
affinity purified by Protein A
Liquid
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
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应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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