PC3113

货号 规格 价格(¥)
PC3113S 50ul
PC3113M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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经典一抗-Phospho-Doublecortin (Ser47) Rabbit pAb

Datasheet

Background

Neuronal Marker
Doublecortin (DCX) is a microtubule-associated protein expressed almost exclusively in immature neurons. Neuronal precursors begin to express DCX shortly after exiting the cell cycle, and continue to express DCX for 2-3 weeks as the cells mature into neurons. Downregulation of DCX begins after 2 weeks, and occurs at the same time that these cells begin to express, a marker for mature neurons. Due to the nearly exclusive expression of DCX in developing neurons, this protein has been used increasingly as a marker for neurogenesis. Indeed, the levels of DCX expression increase in response to exercise, which occurs in parallel with increased BrdU labelling, currently a "gold standard" in measuring neurogenesis.

Alternative Names

Doublecortin (phospho S47);
p-Doublecortin (phospho S47);
DBCN;
DBCN;
Dbct;
Dbct;
DC;
DC;
DCX;
DCX;
DCX_HUMAN;
Doublecortex;
Doublecortex;
Doublin;
FLJ51296;
Lis X;
Lis X;
Lis-X;
Lissencephalin X;
Lissencephalin X;
Lissencephalin-X;
Lissencephaly X linked;
Lissencephaly X linked;
Lissencephaly X linked doublecortin;
Lissencephaly X linked doublecortin;
LISX;
LISX;
Neuronal migration protein doublecortin;
OTTHUMP00000023859;
OTTHUMP00000023860;
OTTHUMP00000216315;
OTTHUMP00000216316;
SCLH;
SCLH;
XLIS;
XLIS.

Reactivity

Human,Mouse,Rat,Chicken,Dog,Cow,Horse

Application

WB,IHC,IF,ICC,FC

Recommended Dilution

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400
FC 1:100

Application Image

Mol Weight

40kD

Gene ID

1641

UniProt

O43602

Uniprot link

Subcellular location

Cytoplasm. Cell projection. Note=Localizes at neurite tips.

Specificity

Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.

Immunogen

KLH conjugated Synthesised phosphopeptide derived from human Doublecortin around the phosphorylation site of Ser47

Source

Rabbit

Clonality

Polyclonal

Isotype

IgG

Purification

affinity purified by Protein A

Formulation

Liquid

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Concentrate

Storage Condition

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

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邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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