L-amino acid transporter protein-2 (LAT2), a non-glycosylated membrane protein, complexes with CD98 to contribute to readsorption of neutral amino acids in renal epithelia and blood-tissue barriers. The gene encoding LAT2 is expressed primarily in the kidney, but also to a lesser extent in placenta, brain, liver, spleen, skeletal muscle, heart, small intestine, and lung. Transfection with the antisense sequence of LAT2 suggests that LAT2 expression plays a major role in net basolateral efflux of cysteine, and points to LAT2 as a candidate gene to modulate cysteine reabsorption. In addition, the CD98/LAT2 heterodimer associates with Integrin ∫1 in intestinal epithelial cells, where ligand binding to CD98 and another cell surface molecule, ICAM-1 differentially regulates LAT2 activity, suggesting a novel mechanism by which events like cell adhesion may affect amino acid transport activity.

hLAT2;
integral membrane protein E16H;
L type amino acid transporter 2;
L-type amino acid transporter 2;
Large neutral amino acids transporter small subunit 2;
LAT2_HUMAN;
LPI PC1;
SLC7A8;
solute carrier family 7 (amino acid transporter light chain, L system), member 8;
solute carrier family 7 (amino acid transporter, L type), member 8;
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8;
Solute carrier family 7 member 8.

Rat,Human,Mouse,Dog,Pig,Horse,Sheep, Orangutan

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

61kD

23428

Q9UHI5

https://www.uniprot.org/uniprotkb/Q9UHI5

Cytoplasm. Basolateral cell membrane. Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi.

Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2.

KLH conjugated synthetic peptide derived from human LAT2

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.