Transfer RNA (tRNA) modifications help regulate the efficiency of mRNA translation by maintaining the correct reading frames. TRM12 (tRNA methyltransferase 12 homolog (S. cerevisiae)), also known as TYW2 (tRNA-yW-synthesizing protein 2) or TRMT12, is a 448 amino acid protein that belongs to the RNA methyltransferase trmD family and TYW2 subfamily. TRM12 is the human homolog of a yeast gene that is essential for the synthesis of yW (wybutosine), a guanosine that stabilizes codon-anticodon associations near the anticodon of phenylalanine tRNA during ribosomal decoding. The gene encoding TRRM12 maps to human chromosome 8, which consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

Alpha amino alpha carboxypropyl transferase TYW2;
FLJ20772;
Homolog of yeast tRNA methyltransferase;
Radical S-adenosyl methionine and flavodoxin domain-containing protein 2;
TRM 12;
TRM12;
TRMT 12;
TRMT12;
tRNA methyltransferase 12;
tRNA methyltransferase 12 homolog;
tRNA wybutosine-synthesizing protein 2 homolog;
tRNA-yW-synthesizing protein 2;
TYW2;
TYW2_HUMAN.

Mouse,Rat,Human,Dog,Pig,Cow,Horse

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

50kD

55039

Q53H54

https://www.uniprot.org/uniprotkb/Q53H54

KLH conjugated synthetic peptide derived from human TRMT12

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.