This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TPA Tissue Plasminogen Activator;
Alteplase;
DKFZp686I03148;
Plasminogen activator tissue;
Plasminogen activator tissue type;
PLAT;
Reteplase;
t PA;
T Plasminogen Activator;
t-PA;
T-plasminogen activator;
Tissue plasminogen activator (t PA);
Tissue type plasminogen activator;
Tissue-type plasminogen activator chain B;
tPA;
TPA_HUMAN;
TPA1.

Human,Mouse,Rat,Dog,Pig,Cow,Sheep

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

59kD

5327

P00750

https://www.uniprot.org/uniprotkb/P00750

Secreted > extracellular space.

Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.

KLH conjugated synthetic peptide derived from human Tissue-type plasminogen activator chain B

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.