Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions.

PTK2 (phospho Y576/Y577); FAK (phospho Y576 + Y577);
FADK 1;
FADK;
FAK related non kinase polypeptide;
FAK1;
FAK1_HUMAN;
Focal adhesion kinase 1;
Focal adhesion Kinase;
Focal adhesion kinase isoform FAK Del33;
Focal adhesion kinase related nonkinase;
FRNK;
p125FAK;
pp125FAK;
PPP1R71;
Protein phosphatase 1 regulatory subunit 71;
Protein tyrosine kinase 2;
Protein-tyrosine kinase 2;
Ptk2;
PTK2 protein tyrosine kinase 2.

Human,Rat,Mouse,Chicken,Dog,Cow,Horse,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

119kD

5747

Q05397

https://www.uniprot.org/uniprotkb/Q05397

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Nucleus. Note=Constituent of focal adhesions. Detected at microtubules.

Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous.

KLH conjugated Synthesised phosphopeptide derived from human FAK around the phosphorylation site of Tyr576/577

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.