FGF1 also designated Heparin-binding growth factor 1 precursor (HBGF-1) ; Acidic fibroblast growth factor (aFGF). heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. Subunit si monomer.FGF1 belongs to the heparin-binding growth factors family. may play a role in neurite outgrowth; may regulate cell differentiation in the nervous system; may act in synergy with fibronectin to enhance neuronal cell adhesion.

Acidic fibroblast growth factor;
Acidic-fibroblast growth factor;
aFGF;
Beta endothelial cell growth factor;
Beta-endothelial cell growth factor;
ECGF;
ECGF beta;
ECGF-beta;
ECGFA;
ECGFB;
Endothelial Cell Growth Factor alpha;
Endothelial Cell Growth Factor beta;
FGF 1;
FGF alpha;
FGF-alpha;
FGF1_HUMAN;
FGFA;
Fibroblast Growth Factor 1 Acidic;
Fibroblast growth factor 1;
GLIO703;
HBGF 1;
HBGF-1;
HBGF1;
Heparin binding growth factor 1;
Heparin binding growth factor 1 precursor;
Heparin-binding growth factor 1
Fibroblast Growth Factor-acidic;
Fibroblast Growth Factor acidic.

Mouse,Rat,Human,Dog,Pig,Horse,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

16kD

2246

P61148

https://www.uniprot.org/uniprotkb/P61148

Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.

Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.

KLH conjugated synthetic peptide derived from human FGF1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.