This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]

2310001G03Rik ;
PAR 4 ;
PAR-4 ;
Pawr ;
PAWR_HUMAN ;
PRKC Apoptosis WT1 Regulator ;
PRKC apoptosis WT1 regulator protein ;
Prostate apoptosis response 4 protein ;
Prostate apoptosis response protein 4 ;
prostate apoptosis response protein PAR-4 ;
Transcriptional repressor Par-4-like protein PAWR ;
Transcriptional repressor PAR4 ;
WT1 Interacting Protein .

Human,Mouse,Rat,Cow,Rabbit

WB

WB 1:500-2000

37kD

5074

Q96IZ0

https://www.uniprot.org/uniprotkb/Q96IZ0

Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.

Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.

KLH conjugated synthetic peptide derived from human PAWR

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.