This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]

EC-SOD; Superoxide Dismutase 3; ALS; ALS1; Cu/Zn superoxide dismutase; EC SOD; Extracellular superoxide dismutase [Cu Zn]; Extracellular superoxide dismutase; Extracellular superoxide dismutase precursor; Homodimer; Indophenoloxidase A; IPOA; Mn superoxide dismutase; SOD 3; SOD; SOD soluble; SOD2; SOD3; Superoxide dismutase 3 extracellular; Superoxide dismutase cystolic; SODE_HUMAN; extracellular superoxide dismutase isoform 1.

Mouse,Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep

WB

WB 1:500-2000

24kD

6649

P08294

https://www.uniprot.org/uniprotkb/P08294

Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.

Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.

KLH conjugated synthetic peptide derived from human SOD3

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.