LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.

LLGL1 + LLGL2 (phospho S650 + S654); LLGL1 + LLGL2 (phospho Ser650 + Ser654); p-LLGL1 + p-LLGL2 (S650 + S654); p-LLGL1/LLGL2 (Ser650 + Ser654); p-LLGL1/LLGL2 (S650 + S654); p-LLGL1/LLGL2 (Ser650/654); DLG4; HGL; HUGL; HUGL1; lethal giant larvae homolog 1; lethal giant larvae homolog 2; Lethal(2) giant larvae protein homolog 1; Lethal(2) giant larvae protein homolog 2; LGL2; LLGL; L2GL1_HUMAN; L2GL2_HUMAN.

Rat,Human,Mouse,Chicken,Dog,Pig,Cow,Horse,GuineaPig,k

ELISA

ELISA 1:5000-10000

117kD

3996

Q15334

https://www.uniprot.org/uniprotkb/Q15334

Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts.

Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.

KLH conjugated synthesised phosphopeptide derived from mouse LLGL1 around the phosphorylation site of Ser650+Ser654

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.