The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

5'-AMP-activated protein kinase catalytic subunit alpha-2;
AAPK2_HUMAN;
ACACA kinase;
Acetyl-CoA carboxylase kinase;
AMPK alpha 2 chain;
AMPK subunit alpha-2;
AMPK2;
AMPK 2;
AMPKa2; AMPK a2; AMPK-a2
AMPKalpha2;
HMGCR kinase;
Hydroxymethylglutaryl-CoA reductase kinase;
PRKAA;
PRKAA2;
Protein kinase AMP activated alpha 2 catalytic subunit;
Protein kinase AMP activated catalytic subunit alpha 2.

Human,Rat,Mouse,Dog,Pig,Cow,Rabbit,Sheep

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

62kD

5563

P54646

https://www.uniprot.org/uniprotkb/P54646

Cytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters.

Widely expressed. Isoform 3 is not expressed in the pituitary gland.

KLH conjugated synthetic peptide derived from human AMPK alpha 2

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.