In eukaryotic cells, the Golgi apparatus receives newly synthesized proteins from the endoplasmic reticulum and delivers them after covalent modification to their destination in the cell. For membrane-directed proteins this process is believed to be carried out via vesicular transport. Correct vesicular transport is determined by specific pairing of vesicle-associated SNAREs (v-SNAREs) with those on the target membrane (t-SNAREs). This complex then recruits soluble NSF attachment proteins (SNAPs) and N-ethylmaleimide-sensitive factor (NSF) to form the highly stable SNAP receptor (SNARE) complex. The formation of a SNARE complex pulls the vesicle and target membranes together and may provide the energy to drive the fusion of the lipid bilayers. Golgi SNARE 27 kDa (GS27) and GS28 belong to the SNARE protein family and are important trafficking proteins between the endoplasmic reticulum and the Golgi and between Golgi subcompartments. GS27 and GS28 both exist as cytoplasmically oriented integral membrane proteins. The human GS27 gene, which maps to chromosome 17q21, is located near a locus implicated in familial essential hypertension, indicating that it is a potential candidate gene for this disease. The human GS28 gene maps to chromosome 17q11.

28 kDa cis Golgi SNARE p28; 28 kDa Golgi SNARE protein; Golgi SNAP receptor complex member 1; Golgi SNARE 28 kDa; GOS28; GOS28/P28; GOSR1; GS25; Gs28; P28; GOSR1_HUMAN.

Mouse,Rat,Human

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

29kD

9527

O95249

https://www.uniprot.org/uniprotkb/O95249

Cell Membrane, Endoplasmic reticulum and Golgi Apparatus

KLH conjugated synthetic peptide derived from human GOSR1/GS28

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.