Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008].

actinin 4;
Actinin alpha 4;
Actinin alpha-4;
Alpha-actinin-4;
α-Actinin-4;
αActinin-4;
actinin4;
ACTN 4;
ACTN4;
ACTN4_HUMAN;
DKFZp686K23158;
F actin cross linking protein;
F-actin cross-linking protein;
Focal segmental glomerulosclerosis 1;
FSGS 1;
FSGS;
FSGS1;
Non muscle alpha actinin 4;
Non-muscle alpha-actinin 4.

Human,Mouse

WB,IHC,IF,ICC

WB 1:200-1000
IHC 1:20-1:100
IF 1:100-1:400
ICC 1:100-1:400

105kD

81

O43707

https://www.uniprot.org/uniprotkb/O43707

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7).

Widely expressed.

KLH conjugated synthetic peptide derived from human alpha Actinin 4

Rabbit

Recombinant

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.