Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. The highly conserved DYNLL proteins were originally identified as light chains for microtubule-based motor protein Dynein. In mammals there are two closely related isoforms expressed, DYNLL1 and DYNLL2 which share 93% sequence identity at the protein level. DYNLL1 (Dynein light chain 1) also designated, DLC8 or PIN (Protein inhibitor of neuronal nitric oxide synthase) has been identified as a protein that interacts with NOS1 resulting in NOS1 inhibition. Dimerization is required for NOS1 activity and DYNLL1 has been shown to destabilize the NOS1 dimer. Nitric oxide may be involved in several processes such as apoptosis, synaptogenesis and neuronal development; thus DYNLL1 is implicated in these processes as well. DYNLL1 is a ubiquitously expressed protein that exhibits high expression in testis and moderate expression in brain. DYNLL2 (Dynein light chain 2) is subject to a unique alternative splicing event which is implicated in Myosin Va binding specificity.

DYNLL2; Dynein light chain 2, cytoplasmic; Dynein;
8 kDa dynein light chain b;
C87222;
cytoplasmic;
Dlc2;
DLC8b;
DNCL1B;
DYL2_HUMAN;
Dynein light chain 2;
Dynein light chain LC8 type 2;
Dynein light chain LC8-type 2;
Dynll2;
MGC17810;

Mouse,Human,Rat,Chicken,Dog,Horse

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

10kD

140735

Q96FJ2

https://www.uniprot.org/uniprotkb/Q96FJ2

Cytoplasm, cytoskeleton.

KLH conjugated synthetic peptide derived from human Dynein light chain 2

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.