The IL-6-type family of cytokines, which includes IL-6 and a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the STAT family are involved in IL-6 family-mediated signal transduction pathways, and upon activation undergo phosphorylation, dimerization and translocation to the nucleus. The duration and intensity of a cell's response to cytokines can be adjusted by the effect of several regulatory mechanisms. One example involves the protein inhibitor of activated signal transducer and activator of transcription (STAT) family (PIAS family) of proteins, which act as negative regulators of STATs in cytokine signaling. PIAS proteins are able to coactivate steroid receptor-dependent transcription as well. Human PIASy is a 510 amino acid transcriptional corepressor of the androgen receptor (AR). In addition, PIASy may regulate p53-mediated events and may direct p53 into a transactivation-independent mode of apoptosis.

E3 SUMO protein ligase PIAS4;
E3 SUMO-protein ligase PIAS4;
FLJ12419;
MGC35296;
PAIASgamma;
PIAS 4;
PIAS gamma;
PIAS-gamma;
PIAS4;
PIAS4_HUMAN;
PIASG;
PIASgamma;
PIASy;
Protein inhibitor of activated STAT 4;
Protein inhibitor of activated STAT protein 4;
Protein inhibitor of activated STAT protein gamma;
Protein inhibitor of activated STAT protein PIASy;
Zinc finger MIZ type containing 6;
ZMIZ 6;
ZMIZ6.

Rat,Human,Mouse,Dog,Pig,Cow,Horse,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

55kD

51588

Q8N2W9

https://www.uniprot.org/uniprotkb/Q8N2W9

Nucleus > PML body. Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.

Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes.

KLH conjugated synthetic peptide derived from human PIASy

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.