G protein-coupled receptors (GPRs or GPCRs), also known as seven transmembrane receptors, heptahelical receptors, or 7TM receptors, are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are integral seven-pass membrane proteins with some conserved amino acid regions. GPR19, an orphan receptor, shows elevated expression during embyronic development of the nervous sytem as well as in specific regions of adult mouse brain, including the olfactory bulb, the hippocampus, hypothalamic nuclei and the cerebellum. The GPR19 gene maps to a location on chromosome 12, which is a frequent target for rearrangement in cancer cells and involved in childhood acute lymphoblastic leukemia (ALL).

GPCR GPR4;G protein coupled receptor 19; G protein coupled receptor 4; G-protein coupled receptor 19; G-protein coupled receptor 4; GPR 4; GPR19; GPR4; GPR4_HUMAN; Probable G protein coupled receptor GPR4; GPCR GPR19.

Human,Mouse

WB,FC

WB 1:500-2000
FC 1ug/Test

41kD

2842

Q15760

https://www.uniprot.org/uniprotkb/Q15760

Cell membrane.

Abundant expression in the brain.

KLH conjugated synthetic peptide derived from human G protein coupled receptor 19

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.