The human chemoattractant receptor-homologous molecule (CRTH2, GPR44, G protein-coupled receptor 44) maps to chromosome 11q12-q13.3 and encodes a 472 amino acid G protein-coupled leukocyte chemoattractant receptor. Chemoattractant receptors present on Th2 cells respond to parasites and play a central role in allergic inflammation; they are absent on type 1 T helper (Th1) cells, which address intracellular bacteria and many viruses. CRTH2 contains seven putative transmembrane domains and mediates signals to the interior of the cell upon exposure to its cognate ligand prostaglandin (PG) D2, which is able to attract basophils, eosinophils, type 2 Th (Th2) cells and type 2 cytotoxic (Tc2) CD8+ T lymphocytes. CRTH2 expression on active Th2 cells influences supportive roles in Th2-type immune reactions. 3.5 kb CRTH2 transcripts are present in thalamus, frontal cortex, pons, hippocampus, hypothalamus and caudate, while 3.4 kb transcripts are present in fetal liver, leukocytes and thymus.

GPCR GPR44; CD294; CD 294; CD294 antigen; Chemoattractant receptor homologous molecule expressed on Th2 cells; chemoattractant receptor-homologous; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH 2; CRTH2; DL1R; DP2 prostaglandin receptor; G Protein Coupled Receptor 44; GPR 44; Gpr44; PD2R2_HUMAN; PTGDR2; Putative G protein coupled receptor 44; Putative G-protein coupled receptor 44; GPCR 44.

Human

WB

WB 1:500-2000

43kD

11251

Q9Y5Y4

https://www.uniprot.org/uniprotkb/Q9Y5Y4

Cell membrane.

KLH conjugated synthetic peptide derived from human GPR44/CD294

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.