In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing (1). GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC (2,3). In addition to GABA receptors, several proteins have been identified as regulators of GABA function, including GAD65, GAD67, GABA transporters and GABARAP (GABAA receptor-associated protein) (4-6). GABARAP associates with GABAA Rg2 to link GABAA receptors to the cytoskeleton (6). The GABARAP protein sequence is similar to light chain-3 of microtubule-associated proteins (MAPs) suggesting that it may be a type of MAP or a component of a MAP complex (6).

ATG 8; ATG8; FLC 3A; FLC3A; GABA(A) receptor associated protein like 2; Gamma aminobutyric acid receptor associated protein like 2; Ganglioside expression factor 2; GATE 16; GATE16; General protein transport factor p16; MAP1 light chain 3 related protein; GABA(A) receptor-associated protein-like 2; Gabarapl2; Gamma-aminobutyric acid receptor-associated protein-like 2; GATE-16; GBRL2_HUMAN; GEF 2; GEF-2; GEF2; Golgi-associated ATPase enhancer of 16 kDa; MAP1 light chain 3-related protein.

Human,Mouse,Rat

WB

WB 1:500-2000

14kD

11345

P60520

https://www.uniprot.org/uniprotkb/P60520

Golgi apparatus.

Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.

KLH conjugated synthetic peptide derived from human GABARAPL2

Rabbit

Recombinant

IgG

affinity purified by Protein A

Liquid

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.