This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L

p63208

6500

Human

WB,IHC,FC

WB 1:500-1:2000
IHC 1:200-1:1000
FC 1:200-1:400

Mouse IgG1

Mouse

Purified recombinant fragment of human SKP1 expressed in E. Coli.

19kDa

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at 4℃ short term. Store at -20℃ long term. Avoid freeze / thaw cycle.