This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

CTS; CTS1; PALB; TBPA; HEL111; HsT2651

p02766

7276

Human

FC

FC 1:200-1:400

Mouse IgG1

Mouse

Purified recombinant fragment of human TTR (AA: 1-147) expressed in E. Coli.

16kDa

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at 4℃ short term. Store at -20℃ long term. Avoid freeze / thaw cycle.