The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

IL6ST; GP130; CDW130; IL-6RB

p40189

3572

Human,Monkey

WB,IHC,IF,ICC,FC

WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:100-1:400
ICC 1:200-1:1000
FC 1:200-1:400

Mouse IgG1

Mouse

Purified recombinant fragment of human CD130 (AA: extra 73-231) expressed in E. Coli.

103.5kDa

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at 4℃ short term. Store at -20℃ long term. Avoid freeze / thaw cycle.