This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

NS7; B-raf; BRAF1; RAFB1; B-RAF1

p15056

673

Human, Mouse, Monkey

WB,IHC,FC

WB 1:500-1:2000
IHC 1:200-1:1000
FC 1:200-1:400

Mouse IgG1

Mouse

Purified recombinant fragment of human BRAF (AA: 299-447) expressed in HEK293-6e.

84.4kda

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at 4℃ short term. Store at -20℃ long term. Avoid freeze / thaw cycle.