This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

NELFA; NELF-A; P/OKcl.15

q9h3p2

7469

Human,Rat

WB,IHC,IF,ICC,FC

WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:100-1:400
ICC 1:200-1:1000
FC 1:200-1:400

Mouse IgG2b

Mouse

Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. Coli.

57.3kDa

PBS, pH 7.4, 40% glycerol, and 0.01% sodium azide.

Store at 4℃ short term. Store at -20℃ long term. Avoid freeze / thaw cycle.