δ-Catenin is a subfamily of catenin proteins with ten armadillo-repeats and includes the proteins catenin delta-1 and catenin delta-2. Catenin delta-2 is expressed in the brain where it is important for normal cognitive development. Like β-catenin and γ-catenin, δ-catenins seem to interact with presenilins. These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion. While β-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-1 catenin has been implicated as a regulator of the NF-κB transcription factor. Palmitoylation of δ-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.

CTNND2, NPRAP

q9uqb3

WB,IHC,IF,ICC,IP

WB 1:1000
IHC 1:200
IF 1:200
ICC 1:100-1:400
IP 1-2μg/sample

Human,Mouse,Rat,Cynomolgus monkey,Pig

Predicted size: 135 kDa

Rabbit

Nucleus, Cell junction, adherens junction, Cell projection, dendrite, Perikaryon.

Protein A affinity purified.

Recombinant Rabbit monoclonal

IgG

Liquid

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.