Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating ''Thr-208'' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system.

Serine/threonine-protein kinase TAO1
Kinase from chicken homolog B (hKFC-B)
MARK Kinase (MARKK)
Prostate-derived sterile 20-like kinase 2 (PSK-2; PSK2; Prostate-derived STE20-like kinase 2)
Thousand and one amino acid protein kinase 1 (TAOK1; hTAOK1)
TAOK1
KIAA1361, MAP3K16, MARKK

q7l7x3

WB,IHC,IF,ICC,FC

WB 1:1000
IHC 1:200-1:1000
IF 1:100-1:400
ICC 1:100
FC 1:1000

Human,Mouse,Rat

Predicted size: 116 kDa

Rabbit

Cytoplasm.

Protein A affinity purified.

Recombinant Rabbit monoclonal

IgG

Liquid

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.