Histone demethylase that demethylates ''Lys-4'' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated ''Lys-4'' of histone H3. Has no effect on tri-methylated ''Lys-4'', mono-, di- or tri-methylated ''Lys-9'', mono-, di- or tri-methylated ''Lys-27'', mono-, di- or tri-methylated ''Lys-36'' of histone H3, or on mono-, di- or tri-methylated ''Lys-20'' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes.

Lysine-specific histone demethylase 2
Flavin-containing amine oxidase domain-containing protein 1
Lysine-specific histone demethylase 1B
KDM1B
AOF1, C6orf193, LSD2

q8nb78

WB

WB 1:2000

Human,Mouse,Rat

Predicted size: 92 kDa

Rabbit

Chromosome. Nucleus.

Protein A affinity purified.

Recombinant Rabbit monoclonal

IgG

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.