The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes to the control of cellular processes that include glucose metabolism, cell division, and contextual memory. PKA Cα is part of a larger protein complex that is responsible for controlling when and where proteins are phosphorylated. Defective regulation of PKA holoenzyme activity has been linked to the progression of cardiovascular disease, certain endocrine disorders and cancers.

cAMP-dependent protein kinase catalytic subunit alpha, PKA C-alpha, PRKACA, PKACA

p17612

WB,IHC,IF,ICC,IP,FC

WB 1:2000
IHC 1:200-1:1000
IF 1:100-1:400
ICC 1:50
IP 1-2μg/sample
FC 1:1000

Human,Mouse,Rat,Monkey

Predicted size: 41 kDa

Rabbit

Cytoplasm, Cell membrane, Membranem Nucleus, Mitochondrion.

Protein A affinity purified.

Recombinant Rabbit monoclonal

IgG

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.