SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain.

SH3 and multiple ankyrin repeat domains protein 2
Shank2
Cortactin-binding protein 1 (CortBP1)
Proline-rich synapse-associated protein 1
SHANK2
CORTBP1, KIAA1022, PROSAP1

q9upx8

WB,IHC,IF,ICC

WB 1:2000
IHC 1:50-1:100
IF 1:200
ICC 1:100-1:400

Human,Mouse,Rat,Cynomolgus monkey

Rabbit

Predicted size: 201 kDa

Apical cell membrane, Cytoplasm, Synapse, Postsynaptic density, Cell projection, growth cone, Cell projection, dendritic spine.

Recombinant Rabbit monoclonal

IgG

Protein A affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.