Activity-regulated cytoskeleton-associated protein is a plasticity protein that in humans is encoded by the ARC gene. The gene is believed to derive from a retrotransposon. The protein is found in the neurons of tetrapods and other animals where it can form virus-like capsids that transport RNA between neurons. ARC mRNA is localized to activated synaptic sites in an NMDA receptor-dependent manner, where the newly translated protein is believed to play a critical role in learning and memory-related molecular processes. Arc protein is widely considered to be important in neurobiology because of its activity regulation, localization, and utility as a marker for plastic changes in the brain. Dysfunction in the production of Arc protein has been implicated as an important factor in understanding various neurological conditions, including amnesia, Alzheimer''s disease, Autism spectrum disorders, and Fragile X syndrome.

Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein (ARC/ARG3.1; Arg3.1), Arc

q9wv31

WB,IHC,IF,ICC

WB 1:2000
IHC 1:200
IF 1:500
ICC 1:100-1:400

Mouse,Rat,Cynomolgus monkey,Pig

Rabbit

Predicted size: 45 kDa

Extracellular vesicle membrane.

Recombinant Rabbit monoclonal

IgG

Protein A affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.