Intraflagellar transport protein 88 homolog is a protein that is encoded by the IFT88 gene. This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. In 2012 a mutation was found to be responsible for a novel form of ciliopathy and anosmia in humans capable of remedy in mice by adenoviral mediated gene therapy. IFT88 has been shown to interact with BAT2 and WDR62.[8][9] WDR62 is required for IFT88 localization to the cilia basal body and the cilia axoneme.

Intraflagellar transport protein 88 homolog
Recessive polycystic kidney disease protein Tg737 homolog
Tetratricopeptide repeat protein 10 (TPR repeat protein 10)
IFT88
TG737, TTC10

q13099

WB,IHC,IF,ICC

WB 1:2000-1:5000
IHC 1:1000
IF 1:100-1:400
ICC 1:50

Human,Mouse,Rat,Monkey

Rabbit

Predicted size: 93 kDa

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cell projection, cilium, cilium basal body, flagellum.

Recombinant Rabbit monoclonal

IgG

Protein A affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.