SMARCC2 (BAF170) is a core subunit of the SWI/SNF chromatin remodeling complex, which regulates gene expression by altering chromatin structure in an ATP-dependent manner. This complex is essential for transcription, DNA replication, and repair, and plays a key role in cell growth, differentiation, and development. SMARCC2/BAF170 enhances the ATPase activity of the catalytic subunit BRG1, facilitating nucleosome remodeling and gene regulation.
During neural development, SMARCC2/BAF170 is part of both the neural progenitor-specific (npBAF) and neuron-specific (nBAF) chromatin remodeling complexes. The npBAF complex supports neural stem cell self-renewal, while the nBAF complex regulates dendrite growth and neuronal gene expression. SMARCC2/BAF170 also plays a critical role in myeloid differentiation, particularly in granulocytopoiesis and neutrophil granule formation. Its expression is tightly regulated, and its upregulation is associated with the loss of pluripotency in embryonic stem cells.

SWI/SNF complex subunit SMARCC2
BRG1-associated factor 170 (BAF170)
SWI/SNF complex 170 kDa subunit
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
SMARCC2
BAF170

q8taq2

WB,IHC,IF,ICC,IP,ChIP

WB 1:5000
IHC 1:1000
IF 1:100-1:400
ICC 1:500
IP 1-2μg/sample

Human,Mouse,Rat

Rabbit

Predicted size: 133 kDa

Nucleus.

Recombinant Rabbit monoclonal

IgG

Protein A affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.