ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1) is a membrane-bound enzyme that hydrolyzes nucleotide triphosphates, such as ATP, into nucleotide monophosphates and pyrophosphate (PPi). It plays a critical role in regulating PPi levels, which are essential for inhibiting bone mineralization and soft tissue calcification. By preventing the growth of hydroxyapatite crystals, ENPP1 helps maintain proper tissue mineralization and prevents ectopic calcification.
ENPP1 is involved in multiple physiological processes, including energy metabolism, purinergic signaling, and the regulation of nucleotide sugar availability in the endoplasmic reticulum and Golgi. It also modulates insulin sensitivity and function, contributing to metabolic regulation. Additionally, ENPP1 has been implicated in melanogenesis and the hydrolysis of 2'',3''-cGAMP, a secondary messenger involved in immune signaling, although its role in this process remains unclear.
Dysregulation or deficiency of ENPP1 is associated with various diseases, including diabetes, obesity, arterial calcification, and autoimmune disorders, making it a significant target for medical research and therapeutic development.

Alkaline phosphodiesterase, Membrane component chromosome 6 surface marker 1, Nucleotide diphosphatase, Nucleotide pyrophosphatase, Phosphodiesterase I/nucleotide pyrophosphatase 1, Plasma-cell membrane glycoprotein PC-1

p22413

WB

WB 1:5000

Human

Rabbit

Predicted size: 105 kDa

Cell membrane, Basolateral cell membrane, Secreted.

Recombinant Rabbit monoclonal

IgG

Protein A affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.