13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
E3 ubiquitin-protein ligase that catalyzes the ''Lys-48''- and/or ''Lys-63''-linked polyubiquitination of various substrates and thereby plays a role in a number of signaling pathways including autophagy, innate immunity, cell proliferation and cell death . Plays a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4 through their polyubiquitination. Participates together with BST2 in antiviral immunity by facilitating the internalization of HIV-1 virions into intracellular vesicles leading to their lysosomal degradation . Possesses also an antiviral activity independently of BST2 by promoting retroviral GAG proteins ubiquitination, redistribution to endo-lysosomal compartments and, ultimately, lysosomal degradation . Catalyzes distinct types of ubiquitination on MAVS and STING1 at different phases of viral infection to promote innate antiviral response . Mediates the ''Lys-48''-linked ubiquitination of MAVS leading to its proteasomal degradation and ubiquitinates STING1 via ''Lys-63''-linked polyubiquitination, critical for its oligomerization and the subsequent recruitment of TBK1 . Plays a positive role in the autophagosome-lysosome fusion by interacting with STX17 and enhancing its stability without affecting ''Lys-48''- or ''Lys-63''-linked polyubiquitination levels, which in turn promotes autophagosome maturation . Negatively regulates TLR-induced expression of proinflammatory cytokines by catalyzing ''Lys-11''-linked ubiquitination of RAB1A and RAB13 to inhibit post-ER trafficking of TLRs to the Golgi by RAB1A and subsequently from the Golgi apparatus to the cell surface by RAB13 .
E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364),RNF115 ZNF364
q9y4l5
27246
Human
IHC,IF,ICC
IHC 1:200IF 1:100-1:400ICC 1:100-1:400
QVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASASN
Mouse
Monoclonal
IgG2a
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide
Store at -20°C. Do not aliquot the antibody
艾比玛特医药科技（上海）有限公司
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张经理：手机13122150513（微信同号）
微信客服
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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