Thiol-dependent isopeptidase that specifically cleaves UFM1, a ubiquitin-like modifier protein, from conjugated proteins, such as CD274/PD-L1, CYB5R3, DDRGK1, MRE11, RPL26/uL24, TRIP4 and RPL26/uL24 . While it is also able to mediate the processing of UFM1 precursors, a prerequisite for conjugation reactions, UFSP2 mainly acts as a protein deUFMylase that mediates deconjugation of UFM1 from target proteins . Mediates deUFMylation of RPL26/uL24, a critical step to release the UFM1 ribosome E3 ligase complex during the recycling of 60S ribosome subunits from the endoplasmic reticulum . Catalyzes deUFMylation of TRIP4, regulating intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation .

Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-)

q9nuq7, q99k23, q5xib4

Human, Mouse, Rat

WB,IHC,IF,ICC

WB 1:1000-1:5000
IHC 1:50-1:100
IF 1:100
ICC 1:100

~54 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.