Orphan nuclear receptor. Binds the NGFI-B response element 5'-AAAGGTCA-3' . Binds 9-cis-retinoic acid outside of its ligand-binding domain . Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation . Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle . Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter . May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration . Plays a role in the vascular response to injury . ; In the cytosol, upon its detection of both bacterial lipopolysaccharide and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.

Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)

p22736

Human,Mouse,Rat

WB

WB 1:1000-1:5000

~65 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.