Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling . Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin . Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP . Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia . Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP . Also degrades an aberrant frameshifted 40-residue form of NPPA which is associated with familial atrial fibrillation in heterozygous patients . Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide that is presented to cytotoxic T lymphocytes by MHC class I. ; The membrane-associated isoform acts as an entry receptor for varicella-zoster virus .

Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)

p14735

Human, Mouse, Rat

WB,IF,ICC,FC

WB 1:2000-1:10000
IF 1:20
ICC 1:20
FC 1:20

~118 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.