Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and VJ recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity . Involved in VJ recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences . Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors . In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE . Has antimicrobial activity in gastrointestinal epithelial tissues . Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity . Involved in modulation of neurogenesis probably by regulation of neural stem proliferation . Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway .

High mobility group protein B2 (High mobility group protein 2) (HMG-2)

p26583

Human,Mouse,Rat

WB,IHC,IF,ICC

WB 1:2000-1:20000
IHC 1:200-1:500
IF 1:200-1:500
ICC 1:200-1:500

~25 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.