Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus . Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner . Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells . ; In the mitochondria, together with PHB2, forms large ring complexes in the inner mitochondrial membrane and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan . The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner . Regulates mitochondrial respiration activity playing a role in cellular aging . The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation . Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 . ; In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses . Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells . ; In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates . Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation .

Prohibitin 1

p35232

Human,Mouse,Rat

WB,IHC,IF,ICC,IP

WB 1:1000
IHC 1:100-1:200
IF 1:100-1:200
ICC 1:100-1:200
IP 1:100

~30 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.