Transcription coregulator that can have both coactivator and corepressor functions . Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein intracellular domain . Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis . May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' at double-strand breaks , recruiting other pro-apoptosis factors such as MAPK8/JNK1 . Required for histone H4 acetylation at double-strand breaks . Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity . Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 . Associates with chromatin in a region surrounding the CASP4 transcriptional start site . Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning . Plays a role in the maintenance of lens transparency . May play a role in muscle cell strength . Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment .

Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)

o00213

Human

WB,IHC

WB 1:1000-1:5000
IHC 1:50-1:100

~78 kD

Rabbit

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.